Microarrays for an Integrative Genomics (Computational Molecular Biology)

by Isaac S. Kohane, Alvin Kho, Atul J. Butte

Publisher: MIT Press
ISBN: 026211271X

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Book Description

Functional genomics the deconstruction of the genome to determine the biological function of genes and gene interactions--is one of the most fruitful new areas of biology. The growing use of DNA microarrays allows researchers to assess the expression of tens of thousands of genes at a time. This quantitative change has led to qualitative progress in our ability to understand regulatory processes at the cellular level.

This book provides a systematic introduction to the use of DNA microarrays as an investigative tool for functional genomics. The presentation is appropriate for readers from biology or bioinformatics. After presenting a framework for the design of microarray-driven functional genomics experiments, the book discusses the foundations for analyzing microarray data sets, genomic data-mining, the creation of standardized nomenclature and data models, clinical applications of functional genomics research, and the future of functional genomics.

Book Info

Provides a systematic introduction to the use of CNA microarrays as an investigative tool for functional genomics. The presentation is appropriate for readers from biology or bioinformatics.

Customer Reviews

This is the book we have all been waiting for. The authors do an amazing job of describing, in understandable terms, how to perform meaningful microarray experiments. I highly recommend this seminal work.

This book is an excellent educational source for the rapidly exploding field of bioinformatics, particularly in the area of functional genomics- i.e. teasing out the functions of the thousands of genes in the genome. Described in clear detail are many approaches to the complex analysis of RNA expression array data, including the appropriate situations for use and advantages and pitfalls inherent in each approach. The reader will learn biological theory integrated with mathematical concepts. The authors also clearly have a lucid understanding of the technical strengths and weaknesses of microarray technology.

The data miners have arrived and are pitching camp around the genomic wellsprings of data opened up by DNA microarrays. To extract the good stuff, however, experiments must be designed and analyzed with care.

This book gathers the pragmatic, candid, useful advice from the pioneers that you'll want to have if you want to join them.

... but they didn't tell us that nobody knew what it meant. Reading this book is a good first step toward understanding the next 30 years of genetics research.